NU7026

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP04736CAS No. ：154447-35-5Purity：98%

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CAS No.	154447-35-5	Cat. No.	BCP04736
Name	NU7026
Synonyms	LY293646;NU 7026;NU-7026;LY 293646;LY-293646;
SMILES
Chemical Name
Formula	C17H15NO3	M. Wt	281.31
Purity	98%	Storage	Store at 4-8°C
Description	NU7026 potentiates ionizing radiation induced cytotoxicity in a concentration-dependent manner in V3YAC and PARP-1+/+ cells. NU7026 completely abolishes potentially lethal damage recovery in growth-arrested cells. NU7026 inhibits DNA DSB repair by 56% in the V3YAC cell line.NU7026 (10 μM) potentiates the growth inhibitory effects of idarubicin, daunorubicin, doxorubicin, etoposide, mAMSA, and mitoxantrone with PF50 values ranging from approximately 19 for mAMSA to approximately 2 for idarubicin in K562 cells. NU7026 (10 μM) also potentiates the growth inhibitory effect of etoposide in this leukemia cell line with a PF50 value of 10.53. NU7026 (10 μM) enhances the etoposide-induced cell cycle G2 blockade in K562 cells. NU7026 potentiates topo II poisons involves inhibition of nonhomologous end joining and a G2/M checkpoint arrest.NU7026 (10 μM) exposure of 4 h in combination with 3 Gy radiation is required for a significant radiosensitisation effect in CH1 human ovarian cancer cells.NU7