VX-984

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP29319CAS No. ：1562396-65-9Purity：98%

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CAS No.	1562396-65-9	Cat. No.	BCP29319
Name	VX-984
Synonyms	VX 984; VX984; M9831; M-9831; M 9831;
SMILES	O=C(C1=CC=NC2=C([C@H](C)CNC3=NC=NC(C4=C([2H])N=C(C)N=C4[2H])=C3)C=CC=C12)N
Chemical Name
Formula	C22H19D2N7O	M. Wt	401.46
Purity	98%	Storage	Store at 4-8°C
Description	VX-984, also known as M9831, is an ATP-competitive inhibitor of the catalytic subunit of DNA-dependent protein kinase (DNA-PK), with potential sensitizing and enhancing activities for both chemo- and radiotherapies. Upon administration, VX-984 binds to and inhibits the catalytic subunit of DNA-PK, thereby interfering with the non-homologous end joining (NHEJ) process and preventing repair of DNA double strand breaks (DSBs) caused by ionizing radiation or chemotherapeutic treatment. This increases chemo- and radiotherapy cytotoxicity and leads to enhanced tumor cell death. The enhanced ability of tumor cells to repair DSBs plays a major role in the resistance of tumor cells to chemo- and radiotherapy; DNA-PK plays a key role in the NHEJ pathway and DSB repair.