IEM1754 dihydrobromide
Data Sheet
For research use only. Not for human use.
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| CAS No. | 162831-31-4 | Cat. No. | BCP06096 |
| Name | IEM1754 dihydrobromide | ||
| Synonyms | IEM-1754;IEM 1754; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C16H30N2.2HBr | M. Wt | 412.25 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | IEM 1754 is an adamantane derivative. IEM 1754 causes use- and voltage-dependent block of open channels of recombinant AMPA receptors. This antagonism is dependent on receptor subunit composition, channels gated by recombinant, homomeric GluR1 and GluR3 receptors exhibites a higher sensitivity to block than those gated by receptors containing edited GluR2 subunits.IEM-1754 block of GluR2-containing AMPAR is enhanced by hyperpolarization in agreement with the classical single-exponential model. In contrast, the block of GluR2-lacking AMPAR is reduced by hyperpolarization. | ||
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