A-1210477
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1668553-26-1 | Cat. No. | BCP15988 |
| Name | A-1210477 | ||
| Synonyms | A1210477;A 1210477; | ||
| SMILES | O=C(C(N1CCN2CCOCC2)=C(CCCOC3=C4C=CC=CC4=CC=C3)C5=C1C(C6=C(COC7=CC=C(N8CCN(S(=O)(N(C)C)=O)CC8)C=C7)N(C)N=C6C)=CC=C5)O | ||
| Chemical Name | |||
| Formula | C46H55N7O7S | M. Wt | 850.04 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | A-1210477 is a potent and selective MCL-1 inhibitor. A-1210477 induces the hallmarks of intrinsic apoptosis and demonstrates single agent killing of multiple myeloma and non-small cell lung cancer cell lines. A-1210477 synergizes with the BCL-2/BCL-XL inhibitor navitoclax to kill a variety of cancer cell lines. A-1210477 is a potential therapeutics for the treatment of cancer. The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known resistance factor for small-molecule BCL-2 family inhibitors such as ABT-263 (navitoclax), making it an attractive therapeutic target. | ||
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