Varespladib sodium
Data Sheet
For research use only. Not for human use.
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| CAS No. | 172733-42-5 | Cat. No. | BCP20960 |
| Name | Varespladib sodium | ||
| Synonyms | LY315920 sodiuM salt;LY-315920; LY315920; LY 315920; | ||
| SMILES | CCC1=C(C2=C(N1CC3=CC=CC=C3)C=CC=C2OCC(=O)[O-])C(=O)C(=O)N.[Na+] | ||
| Chemical Name | |||
| Formula | C21H19N2O5·Na | M. Wt | 402.38 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Varespladib Sodium is an intravenously administered inhibitor of secretory phospholipase A2 (sPLA2) with orphan drug designation.Varespladib, aslo known as LY315920, is a secreted phospholipase A2 (sPLA2) inhibitor (IC50 = 50 - 750 nM for a range of sPLA2 isoforms). Varespladib reduces atherosclerosis and aneurysm formation in ApoE-/- mice and in guinea pigs. Varespladib significantly reduces the post-ACS inflammatory response in those with and without diabetes. Varespladib may be potentially useful for treatment of coronary artery disease. | ||
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