SDZ 220-581

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP06933CAS No. ：174575-17-8Purity：98%

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CAS No.	174575-17-8	Cat. No.	BCP06933
Name	SDZ 220-581
Synonyms	SDZ220581;
SMILES
Chemical Name
Formula	C16H20ClN2O5P	M. Wt	386.77
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: Wake-promoting doses of LSN2463359 and LSN2814617 attenuated deficits in performance induced by the competitiveNMDA receptor antagonist SDZ 220,581 in two tests of operant behaviour: the variable interval 30 s task and the DMTP task . in vivo: Administration of SDZ 220-581 or CGS 19755 was associated with a robust reduction in PPI, whereas L-701,324, 4-Cl-KYN or MLA failed to alter PPI [2]. With the most active agent, SDZ 220-581, full protection against maximal electroshock seizures (MES) was obtained at oral doses of 10 mg/kg in rats and in mice. The compound had a fast onset (< or = 1 hr) and a long duration (> or = 24 hr) of action . Rats were pretreated with clozapine (0 or 5.0 mg/kg) or haloperidol (0 or 0.1 mg/kg), together with SDZ 220-581 (0 or 2.5 mg/kg), and tested. SDZ 220-581 and SDZ EAB-515 decreased PPI without affecting startle magnitude.