IC 261
Data Sheet
For research use only. Not for human use.
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| CAS No. | 186611-52-9 | Cat. No. | BCP16652 |
| Name | IC 261 | ||
| Synonyms | IC-261;IC261;SU5607; SU-5607; SU 5607; SU 5607; | ||
| SMILES | O=C1NC2=C(C=CC=C2)/C1=CC3=C(OC)C=C(OC)C=C3OC | ||
| Chemical Name | |||
| Formula | C18H17NO4 | M. Wt | 311.33 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SU5607, also known as IC-261, is a potent and selective CK1 inhibitor. IC261 triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. At low micromolar concentrations IC261 inhibits cytokinesis causing a transient mitotic arrest. IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation. IC261 binds to tubulin with an affinity similar to colchicine and is a potent inhibitor of microtubule polymerization. This activity accounts for many of the diverse biological effects of IC261 and, most importantly, for its selective cancer cell killing. | ||
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