LH846
Data Sheet
For research use only. Not for human use.
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| CAS No. | 639052-78-1 | Cat. No. | BCP09669 |
| Name | LH846 | ||
| Synonyms | LH 846;LH-846; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C16H13ClN2OS | M. Wt | 316.81 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | LH846 inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. Shown to lengthen the circadian period in U2OS cells, with minimal effect on amplitude. Treatment with LH846 reduced the PER1 mobility shift and PER1 clearance in a dose-dependent manner, indicating that CKIδ-dependent phosphorylation and subsequent degradation of PER1 protein is inhibited by LH846 treatment. Previous genetic studies demonstrated an important role of CKI-dependent phosphorylation of PER protein in period regulation, supporting the period lengthening effect of LH846 through PER1 protein phosphorylation . | ||
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