Pomalidomide
Data Sheet
For research use only. Not for human use.
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| CAS No. | 19171-19-8 | Cat. No. | BCP02890 |
| Name | Pomalidomide | ||
| Synonyms | CC-4047;Actimid;CC4047;CC 4047; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C13H11N3O4 | M. Wt | 273.24 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Pomalidomide inhibits lipopolysaccharide (LPS) stimulated TNF-alpha release in human PBMC and in human whole blood with IC50 values of 13 nM and 25 nM, respectively. Pomalidomide inhibits the growth of T regulatory cells which is stimulated by IL-2 with an IC50 of ~1 μM.Treatment with Pomalidomide (6.4 nM-10 μM) increases the production of IL-2 in human peripheral blood T cells, and is slightly more potent in the CD4+ subset than in the CD8+ subset. Pomalidomide is significantly more potent than CC-5013 at elevating IL-2, IL-5, and IL-10 levels, but only slightly more potent than CC-5013 at elevating IFN-γ levels. Pomalidomide enhances SEE and Raji cells induced AP-1 transcriptional activity in Jurkat cells in a dose-dependent manner, with a maximal enhancement of 4-fold at 1 μM.Exposure of Raji cells to various concentrations of Pomalidomide (2.5-40 μg/mL) for 48 hours leads to a significant decrease in cell proliferation and DNA synthesis. There is a reduction of ~40% compared to veh | ||
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