JAK2 Inhibitor V Z3
Data Sheet
For research use only. Not for human use.
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| CAS No. | 195371-52-9 | Cat. No. | BCP06498 |
| Name | JAK2 Inhibitor V Z3 | ||
| Synonyms | Z3;NSC 42834;NSC-42834;NSC42834; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C23H24N2O | M. Wt | 344.45 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Z3 selectively inhibited Jak2 kinase function with no effect on Tyk2 or c-Src kinase function. Z3 significantly inhibited proliferation of the Jak2-V617F-expressing, human erythroleukemia cell line, HEL 92.1.7. The Z3-mediated reduction in cell proliferation correlated with reduced Jak2 and STAT3 tyrosine phosphorylation levels as well as marked cell cycle arrest. Finally, Z3 inhibited the growth of hematopoietic progenitor cells isolated from the bone marrow of an essential thrombocythemia patient harboring the Jak2-V617F mutation and a polycythemia vera patient carrying a Jak2-F537I mutation. | ||
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