Rimiducid New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP20825CAS No. ：195514-63-7Purity：98%

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CAS No.	195514-63-7	Cat. No.	BCP20825
Name	Rimiducid
Synonyms	AP1903;AP 1903;AP-1903;
SMILES	CCC(C1=CC(=C(C(=C1)OC)OC)OC)C(=O)N2CCCCC2C(=O)OC(CCC3=CC(=C(C=C3)OC)OC)C4=CC(=CC=C4)OCC(=O)NCCNC(=O)COC5=CC=CC(=C5)C(CCC6=CC(=C(C=C6)OC)OC)OC(=O)C7CCCCN7C(=O)C(CC)C8=CC(=C(C(=C8)OC)OC)OC
Chemical Name
Formula	C78H98N4O20	M. Wt	1411.63
Purity	98%	Storage	Store at 4-8°C
Description	AP1903, also known as Rimiducid, is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity. This agent is used to homodimerize the Fv-containing drug-binding domains of genetically engineered receptors such as the iCD40 receptor of the autologous dendritic cell vaccine BP-GMAX-CD1, resulting in receptor activation.