Bardoxolone methyl New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 218600-53-4 | Cat. No. | BCP04660 |
| Name | Bardoxolone methyl | ||
| Synonyms | CDDO Methyl ester; CDDOMe; NSC 713200; RTA 402; RTA-402; RTA402; TP-155; TP155; TP 155; | ||
| SMILES | O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4(C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC | ||
| Chemical Name | |||
| Formula | C32H43NO4 | M. Wt | 505.69 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Bardoxolone methyl (also known as “RTA 402” and “CDDO-methyl ester”) is an orally-available first-in-class synthetic triterpenoid belonging to the antioxidant inflammation modulator (AIM) class. It is the most potent known inducer of the Nrf2 pathway to enter clinical development and works to suppress both oxidative stress and inflammation. Bardoxolone methyl is currently being developed by Reata Pharmaceuticals, Inc. in partnership with Abbott Laboratories and Kyowa Hakko Kirin, for the treatment of advanced chronic kidney disease (CKD) in type 2 diabetes mellitus patients. | ||
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