PF03491390
Data Sheet
For research use only. Not for human use.
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| CAS No. | 254750-02-2 | Cat. No. | BCP07463 |
| Name | PF03491390 | ||
| Synonyms | Emricasan;IDN6556;IDN 6556;IDN-6556;PF-03491390;PF 03491390; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C26H27F4N3O7 | M. Wt | 569.5 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Emricasan, also known as IDN 6556 and PF 03491390, is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases. Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis. IDN6556 facilitates marginal mass islet engraftment in a porcine islet autotransplant model. Oral IDN-6556 may lower aminotransferase activity in patients with chronic hepatitis C. Orally-administered PF-03491390 is retained in the liver for prolonged periods with low systemic exposure, exerting a hepatoprotective effect against alpha-fas-induced liver injury in a mouse model. | ||
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