Cinacalcet hydrochloride New
Data Sheet
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| CAS No. | 364782-34-3 | Cat. No. | BCP02533 |
| Name | Cinacalcet hydrochloride | ||
| Synonyms | Cinacalcet HCl;Mimpara;Sensipar;AMG-073;AMG 073;AMG073; | ||
| SMILES | CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl | ||
| Chemical Name | |||
| Formula | C22H22F3N.HCl | M. Wt | 393.88 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Cinacalcet Hydrochloride is the orally bioavailable hydrochloride salt of the calcimimetic cinacalcet. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels. In addition, by reducing PTH levels, cinacalcet may reduce PSA levels; PTH appears to raise PSA levels and may increase prostate cancer cell growth. | ||
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