SVT-40776
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CAS No. | 385367-47-5 | Cat. No. | BCP22673 |
Name | SVT-40776 | ||
Synonyms | SVT40776; Tarafenacin; SVT 40776; | ||
SMILES | |||
Chemical Name | |||
Formula | C25H26F4N2O8 | M. Wt | 408.39 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Tarafenacin, also known as SVT-40776, is a novel M3 muscarinic receptor antagonist under development for the treatment of overactive bladder. SVT-40776 shows highly selective for M(3) over M(2) receptors (Ki = 0.19 nmol.L(-1) for M(3) receptor affinity). SVT-40776 is a potent inhibitor of M(3) receptor-related detrusor contractile activity. The absence of effects on isolated atria preparations represents an interesting characteristic and suggests that SVT-40776 may lack unwanted cardiac effects; a feature especially relevant in a compound intended to treat mainly elderly patients. |
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