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SVT-40776 Chemical Structure

SVT-40776

Data Sheet For research use only. Not for human use.
Cat. No. :BCP22673CAS No. :385367-47-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 385367-47-5 Cat. No. BCP22673
Name SVT-40776
Synonyms SVT40776; Tarafenacin; SVT 40776;
SMILES
Chemical Name
Formula C25H26F4N2O8 M. Wt 408.39
Purity 98% Storage Store at 4-8°C
Description Tarafenacin, also known as SVT-40776, is a novel M3 muscarinic receptor antagonist under development for the treatment of overactive bladder. SVT-40776 shows highly selective for M(3) over M(2) receptors (Ki = 0.19 nmol.L(-1) for M(3) receptor affinity). SVT-40776 is a potent inhibitor of M(3) receptor-related detrusor contractile activity. The absence of effects on isolated atria preparations represents an interesting characteristic and suggests that SVT-40776 may lack unwanted cardiac effects; a feature especially relevant in a compound intended to treat mainly elderly patients.
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