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Tandutinib Chemical Structure

Tandutinib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01370CAS No. ：387867-13-2Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 387867-13-2 Cat. No. BCP01370
Name Tandutinib
Synonyms MLN518;CT53518;MLN 518;CT 53518;MLN-518;CT-53518;
SMILES
Chemical Name
Formula C31H42N6O4 M. Wt 562.7
Purity 98% Storage Store at 4-8°C
Description Tandutinib has little activity against EGFR, FGFR, KDR, InsR, Src, Abl, PKC, PKA and MAPKs. Tandutinib inhibits IL-3-independent cell growth and FLT3-ITD autophosphorylation with an IC50 of 10-100 nM. Tandutinib also inhibits the proliferation of human leukemia Ba/F3 cells containing FLT3-ITD mutations with IC50 values of 10-30 nM, and the FLT3-ITD-positive Molm-13 and Molm-14 cells with an IC50 of 10 nM. In FLT3-ITD-positive Molm-14 cells but not the FLT3-ITD-negative THP-1 cells, Tandutinib tre
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