PYR 41

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP10065CAS No. ：418805-02-4Purity：98%

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CAS No.	418805-02-4	Cat. No.	BCP10065
Name	PYR 41
Synonyms	PYR-41;PYR41;
SMILES
Chemical Name
Formula	C17H13N3O7	M. Wt	371.3
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: PYR-41 increased total sumoylation in cells. The molecular basis for this is unknown; however, increased sumoylation was also observed in cells harboring temperature-sensitive E1. Functionally, PYR-41 attenuates cytokine-mediated nuclear factor-kappaB activation. This correlates with inhibition of nonproteasomal (Lys-63) ubiquitylation of TRAF6, which is essential to IkappaB kinase activation. PYR-41 also prevents the downstream ubiquitylation and proteasomal degradation of IkappaBalpha. Furthermore, PYR-41 inhibits degradation of p53 and activates the transcriptional activity of this tumor suppressor . PYR-41 is a small molecule with previously described UBE1 inhibitory activity. PYR-41 blocks ubiquitination reactions but paradoxically leads to the accumulation of high MW ubiquitinated proteins.