BMS345541

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP06508CAS No. ：445430-58-0Purity：98%

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CAS No.	445430-58-0	Cat. No.	BCP06508
Name	BMS345541
Synonyms	IKK Inhibitor III;BMS 345541;BMS-345541;
SMILES
Chemical Name
Formula	C14H17N5	M. Wt	255.32
Purity	98%	Storage	Store at 4-8°C
Description	BMS-345541 dose-dependently inhibits the TNF-α-stimulated phosphorylation of IκBα in THP-1 monocytic cells with an IC50 of ~4 μM. BMS-345541 inhibits lipopolysaccharide-stimulated tumor necrosis factorα, interleukin-1β, interleukin-8, and interleukin-6 in THP-1 cells with IC50 values in the 1- to 5 μM range. BMS-345541 binds in a mutually exclusive manner with respect to a peptide inhibitor corresponding to amino acids 26 - 42 of IκBα with Ser-32 and Ser-36 changed to aspartates and in a non-mutually exclusive manner with respect to ADP. BMS-345541 binds to similar allosteric sites on IKK-1 and IKK-2, which then affects the active sites of the subunits differently. BMS-345541 affects several mitotic cell cycle transitions, including mitotic entry, prometaphase to anaphase progression and cytokinesis. Adding BMS-345541 to the cells released form arrest in G-phase blocks the activation of Aurora A, B, and C, Cdk1 activation and histone H3 phosphorylation. Treatment of the mitotic cells w