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Pyridone 6 Chemical Structure

Pyridone 6

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01959CAS No. ：457081-03-7Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 457081-03-7 Cat. No. BCP01959
Name Pyridone 6
Synonyms Merck-5;CMP 6;
SMILES FC1=CC2=C(C(NC=C3)=O)C3=C(N=C(C(C)(C)C)N4)C4=C2C=C1
Chemical Name
Formula C18H16FN3O M. Wt 309.34
Purity 98% Storage Store at 4-8°C
Description Pyridone 6 displays potent inhibitory activity against JAK1 (IC50 = 15 nM for murine JAK1), JAK2 (IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk2 (IC50 = 1 nM). Pyridone 6 is therapeutic for AD by modulating the balance of Th2 and Th17. JAK inhibitor Pyridone 6 suppresses asthmatic responses by inhibiting Th2 inflammation and that application of PLGA nanoparticles improves the therapeutic potency of Pyridone 6. Inhibition of JAK may be useful for the treatment of bone-resorptive diseases, such as osteoporosis. Pyridone 6 is a more sensitive and specific inhibitor of JAK-STAT3 activity compared with AG490 and potently inhibited the growth of primary myeloma cells and myeloma-derived cell lines grown on BMSCs.
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