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Alvespimycin Chemical Structure

Alvespimycin

Data Sheet For research use only. Not for human use.
Cat. No. :BCP09078CAS No. :467214-20-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 467214-20-6 Cat. No. BCP09078
Name Alvespimycin
Synonyms KOS 1022; KOS-1022; KOS1022; 17-DMAG;150270-08-9;
SMILES CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC
Chemical Name
Formula C32H48N4O8 M. Wt 616.76
Purity 98% Storage Store at 4-8°C
Description Alvespimycin is an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.
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