UMI77
Data Sheet
For research use only. Not for human use.
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| CAS No. | 518303-20-3 | Cat. No. | BCP09696 |
| Name | UMI77 | ||
| Synonyms | UMI-77;UMI 77;2-((4-((4-bromophenyl)sulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C18H14BrNO5S2 | M. Wt | 468.34 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | UMI-77 is a selective Mcl-1 inhibitor with a Ki value of 490 nM and exhibits selectivity over other members of the Bcl-2 family (Kis = 5.3, 23.8, 33.0, and 8.2 μM) for A1/Bfl-1, Bcl-2, Bcl-xL, and Bcl-W, respectively).UMI-77 inhibits the growth of various pancreatic cancer cell lines with IC50s values ranging from 3.4-16.1 μM, inducing apoptosis through activation of the intrinsic apoptotic pathway and/or Bax conformational change. | ||
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