Tofacitinib citrate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 540737-29-9 | Cat. No. | BCP07333 |
| Related Products | 477600-75-2（Tofacitinib） | ||
| Name | Tofacitinib citrate | ||
| Synonyms | CP-690550;Tasocitinib citrate; CP-690550 citrate; CP 690550 citrate; CP690550 citrate; | ||
| SMILES | CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O | ||
| Chemical Name | |||
| Formula | C16H20N6O.C6H8O7 | M. Wt | 504.49 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Tofacitinib, also known as tasocitinib, CP-690550, is a Janus kinase (JAK) inhibitor. Tofacitinib modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. JAK enzymes transmit cytokine signaling through pairing of JAKs (e.g., JAK1/JAK3, JAK1/JAK2, JAK1/TyK2, JAK2/JAK2). Tofacitinib inhibited the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50 of 406, 56, and 1377 nM, respectively. Tofacitinib citrate was approved for for the treatment of adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate. It may be used as monotherapy or in combination with methotrexate or other nonbiologic disease-modifying antirheumatic drugs (DMARDs). | ||
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