RTICBM-189 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 551909-15-0 | Cat. No. | BCP44866 |
| Name | RTICBM-189 | ||
| Synonyms | RTICBM 189; RTICBM189; | ||
| SMILES | O=C(NCCC1=CC=CC(Cl)=C1)NC2=CC=C(Cl)C=C2 | ||
| Chemical Name | |||
| Formula | C15H14Cl2N2O | M. Wt | 309.19 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | RTICBM-189 is a Urea derivative and a CB1 allosteric modulator. RTICBM-189 showed no activity at >50 protein targets and excellent brain permeation but relatively low metabolic stability in rat liver microsomes. Pharmacokinetic studies in rats confirmed the excellent brain exposure of 31 with a brain/plasma ratio Kp of 2.0. Importantly, intraperitoneal administration of RTICBM-189 significantly and selectively attenuated the reinstatement of the cocaine-seeking behavior in rats without affecting locomotion. | ||
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