Pifithrin-α

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP06357CAS No. ：63208-82-2Purity：98%

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CAS No.	63208-82-2	Cat. No.	BCP06357
Name	Pifithrin-α
Synonyms	PFTα;Pifithrin-alpha;Pifithrin;
SMILES
Chemical Name
Formula	C16H18N2OS.HBr	M. Wt	367.3
Purity	98%	Storage	Store at 4-8°C
Description	Pifithrin-α inhibits p53-dependent transactivation of p53-responsive genes in ConA cells. Pifithrin-α (10 μM) inhibits apoptotic death of C8 cells induced by Dox, etoposide, Taxol, cytosine arabinoside. Pifithrin-α inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Pifithrin-α may modulate the nuclear import or export (or both) of p53 or may decrease the stability of nuclear p53.Pifithrin-α (100-200 nM) completely suppresses the camptothecin-induced increase in the level of p53 DNA binding as well as the p53-responsive gene Bax in hippocampal cell. Pifithrin-α also decreases the basal level of p53 DNA-binding activity. Pifithrin-α (200 nM) protects cultured hippocampal neurons against death induced by DNA-damaging agents. Pifithrin-α (200 μM) stabilizes mitochondrial function, suppresses caspase activation and protects cultured hippocampal neurons against death induced by glutamate and amyloid β-pe