HA14-1
Data Sheet
For research use only. Not for human use.
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| CAS No. | 65673-63-4 | Cat. No. | BCP01804 |
| Name | HA14-1 | ||
| Synonyms | HA 141;HA-14-1; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C17H17BrN2O5 | M. Wt | 409.24 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | HA14-1 is a small molecule and nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of approximately 9 μM. HA14-1 induces the apoptosis of HL-60 cells in a dose-dependent manner via caspase activation. HA14-1 shows cytotoxic effects on HF1A3, HF4.9 and HF28RA follicular lymphoma B cell lines with LC50 of 4.5 μM, 12.6 μM and 8.1 μM respectively. HA14-1 induces apoptosis of HF1A3, HF4.9 and HF28RA cells via caspase and ROS. | ||
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