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BAY 61-3606 Chemical Structure

BAY 61-3606

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP08946CAS No. ：732983-37-8Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 732983-37-8 Cat. No. BCP08946
Name BAY 61-3606
Synonyms BAY 61-3606 HCl;
SMILES
Chemical Name
Formula C20H18N6O3 M. Wt 390.4
Purity 98% Storage Store at 4-8°C
Description Syk Inhibitor IV, BAY 61-3606 (BAY 61-3606) is a cell-permeable imidazopyrimidine compound that acts as a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki = 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. BAY 61-3606 has been shown to inhibit Syk-mediated cellular functions such as inhibition of high glucose-tyrosine phosphorylation of I κ B α and p65 nuclear translocation. In mast cells BAY 61-3606 has inhibited cytokine synthesis, lipid mediation and degranulation. In addition, monocyte and eosinophil activation by B cells and Fc receptors were suppressed by BAY 61-3606.
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