Ketanserin
Data Sheet
For research use only. Not for human use.
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| CAS No. | 74050-98-9;83846-83-7 | Cat. No. | BCP02187 |
| Name | Ketanserin | ||
| Synonyms | Perketan;R-49945;R 49945;R49945;Serefrex;Serepress; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H22FN3O3 | M. Wt | 395.43 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Ketanserin inhibits rat and human 5-HT2C with Ki of 50 and100 nM, respectively and has higher affinity binding for alpha-1 adrenergic (Ki = ~ 40 nM) and Histamine H1 (Ki = 2 nM). Ketanserin can also be used to discriminate between 5-HT1D and 5-HT1B receptor subtypes. Ketanserin has antihypertensive properties. Ketanserin also reduces platelet aggregation produced by serotonin. Ketanserin also has high affinity for alpha-1 adrenergic receptors, and very high affinity for histamine H1 receptors. Ketanserin was shown to reduce the severity and frequency of the vasospasm in Raynaud’s phenomenon. | ||
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