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VER-50589 Chemical Structure

VER-50589

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP09372CAS No. ：747413-08-7Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 747413-08-7 Cat. No. BCP09372
Name VER-50589
Synonyms VER50589;VER 50589;
SMILES
Chemical Name
Formula C19H17ClN2O5 M. Wt 388.8
Purity 98% Storage Store at 4-8°C
Description Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-50589 is an isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM. It produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel. Consistent with inhibition of Hsp90, VER-50589 induces the expression of HSP27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis. VER-50589 shows favorable pharmacokinetics and impairs tumor growth in animals. Importantly, glioblastoma cells do not acquire resistance to VER-50589 and resistance to other Hsp90 inhibitors does not produce cross-resistance to VER-50589.
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