Isradipine

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP06719CAS No. ：75695-93-1Purity：98%

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CAS No.	75695-93-1	Cat. No.	BCP06719
Name	Isradipine
Synonyms	PN 200-110;DynaCirc;Prescal;
SMILES
Chemical Name
Formula	C19H21N3O5	M. Wt	371.39
Purity	98%	Storage	Store at 4-8°C
Description	Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack. Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells. Isradipine may be used to treat mild to moderate essential hypertension.