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17-AAG Chemical Structure

17-AAG

Data Sheet For research use only. Not for human use.
Cat. No. :BCP01735CAS No. :75747-14-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 75747-14-7 Cat. No. BCP01735
Name 17-AAG
Synonyms KOS 953;NSC 330507;Tanespimycin;CP 127374;BMS 722782;
SMILES
Chemical Name
Formula C31H43N3O8 M. Wt 585.69
Purity 98% Storage Store at 4-8°C
Description 17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants.
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