Enalaprilat
Data Sheet
For research use only. Not for human use.
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| CAS No. | 76420-72-9 | Cat. No. | BCP13836 |
| Name | Enalaprilat | ||
| Synonyms | |||
| SMILES | |||
| Chemical Name | |||
| Formula | C18H24N2O5 | M. Wt | 348.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Enalaprilat has the strong inhibitory effect on Aβ42-to-Aβ40-converting activity found in the N-domain of ACE, exhibiting a 10-fold lower IC50 (0.003~0.01 μM) than captopril (0.03~0.1 μM). Enalaprilat (100 nM) blocks protein kinase C epsilon by directly activating bradykinin B1 receptor at the canonical Zn2+ binding site, leading to prolonged nitric oxide (NO) production in cytokine-treated human lung microvascular endothelial cells. Enalaprilat attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with IC50 of 90 mM. | ||
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