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Quinapril hydrochloride Chemical Structure

Quinapril hydrochloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP13022CAS No. :82586-55-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 82586-55-8 Cat. No. BCP13022
Name Quinapril hydrochloride
Synonyms Accupril;Accupro;
SMILES
Chemical Name
Formula C25H31ClN2O5 M. Wt 474.98
Purity 98% Storage Store at 4-8°C
Description Quinapril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used in the treatment of hypertension and congestive heart failure. Quinapril is rapidly de-esterified after absorption to quinaprilat (the active diacid metabolite), a potent angiotensin converting enzyme (ACE) inhibitor. Quinapril is now firmly established as an effective and well tolerated ACE inhibitor for the treatment of patients with hypertension and congestive heart failure. Quinapril 40 mg/day also significantly reduced the incidence of ischaemic events in patients undergoing CABG in one study . An overview of 32 clinical trials of ACE inhibitors in heart failure showed that no significant heterogeneity in mortality was found among enalapril, ramipril, quinapril, captopril, lisinopril, benazepril, perindopril and cilazapril. Initiation of therapy with captopril, ramipril, and trandolapril at least 3 days after an acute MI resulted in all-cause mortality risk reductions of 18 to 27% .
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