Benazepril

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP12672CAS No. ：86541-75-5Purity：98%

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CAS No.	86541-75-5	Cat. No.	BCP12672
Name	Benazepril
Synonyms	Benazeprilum;
SMILES
Chemical Name
Formula	C24H28N2O5	M. Wt	424.49
Purity	98%	Storage	Store at 4-8°C
Description	Benazepril is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor. Animals were randomly divided into 4 groups: sham STNx group (control), STNx group, morning benazepril group (MB) and evening benazepril group (EB).Benazepril was intragastrically administered at a dose of 10 mg/kg/day at 07:00 and 19:00 in the MB group and EB group respectively for 12 weeks. All the animals were synchronized to the light:dark cycle of 12:12 for 12 weeks. Systolic blood pressure (SBP), 24-h urinary protein excretion and renal function were measured at 11 weeks. Blood samples and kidneys were collected every 4 h throughout a day to detect the expression pattern of renin activity (RA), angiotensin II (AngII) and aldosterone (Ald) by radioimmunoassay (RIA) and the mRNA expressi