PRX 08066

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP14768CAS No. ：866206-54-4Purity：98%

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CAS No.	866206-54-4	Cat. No.	BCP14768
Related Products	866206-55-5（PRX-08066 Maleate）
Name	PRX 08066
Synonyms	PRX-08066;PRX08066;
SMILES
Chemical Name
Formula	C19H17ClFN5S	M. Wt	401.89
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: PRX-08066 inhibits 5-HT-induced mitogen-activated protein kinase activation with IC50 of 12 nM and markedly reduces thymidine incorporation with IC50 of 3 nM in Chinese hamster ovary cells expressing the human 5-HT2BR, which suggests that PRX-08066 can potentially inhibit the pathologic 5-HT-induced vascular muscularization associated with PAH . PRX-08066 inhibits cell proliferation with IC50 of 0.46 nM and with a maximum inhibition of 20% and 5-HT secretion with IC50 of 6.9 nM with a maximum inhibition of 30% in the 5-HT(2B) expressing SI-NET cell line, KRJ-I. PRX-08066 inhibits isoproterenol-stimulated 5-HT release with IC50 of 1.25 nM and a maximum inhibition of 60% in NCI-H720 cells. PRX-08066 (0.5 nM) significantly inhibits ERK phosphorylation in KRJ-I cells. PRX-08066 inhibits TGFβ1, CTGF and FGF2 transcription and secretion in KRJ-I cells. PRX-08066 decreases level of transcripts for Ki67 (84%) as well as Ki67 protein (36.8%) associated with an increase in caspase 3 tr