PRX-08066 Maleate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 866206-55-5 | Cat. No. | BCP04753 |
| Related Products | 866206-54-4（PRX08066） | ||
| Name | PRX-08066 Maleate | ||
| Synonyms | PRX-08066 Maleic acid;PRX08066 Maleate; | ||
| SMILES | C1CN(CCC1NC2=C3C=C(SC3=NC=N2)Cl)CC4=CC(=C(C=C4)F)C#N.C(=CC(=O)O)C(=O)O | ||
| Chemical Name | |||
| Formula | C19H17ClFN5S.C4H4O4 | M. Wt | 517.96 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model. Phase 2.PRX-08066 inhibits 5-HT-induced mitogen-activated protein kinase activation with IC50 of 12 nM and markedly reduces thymidine incorporation with IC50 of 3 nM in Chinese hamster ovary cells expressing the human 5-HT2BR, which suggests that PRX-08066 can potentially inhibit the pathologic 5-HT-induced vascular muscularization associated with PAH.PRX-08066 inhibits cell proliferation with IC50 of 0.46 nM and with a maximum inhibition of 20% and 5-HT secretion with IC50 of 6.9 nM with a maximum inhibition of 30% in the 5-HT(2B) expressing SI-NET cell line, KRJ-I. PRX-08066 inhibits isoproterenol-stimulated 5-HT release with IC50 of 1.25 nM and a maximum inhibition of 60% in NCI-H720 cells. | ||
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