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Loxistatin Chemical Structure

Loxistatin

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP20521CAS No. ：88321-09-9Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 88321-09-9 Cat. No. BCP20521
Name Loxistatin
Synonyms EP453;E-64D;E-64-d;E-64c ethyl ester; Aloxistatin;NSC 694281; NSC694281; NSC-694281;EP-453; EP 453;
SMILES O=C([C@]1O[C@@H]1C(N[C@](C(NCCC(C)C)=O)CC(C)C)=O)OCC
Chemical Name
Formula C17H30N2O5 M. Wt 342.43
Purity 98% Storage Store at 4-8°C
Description Aloxistatin (E-64d), is a selective cysteine protease inhibitor or calpain and autophagy inhibitor. E-64d prevents in vitro cerulein- induced trypsinogen activation. E-64d can enter the intact cell and inhibit calpain. E-64d has been shown safe for the treatment of Alzheimer's disease in human. E-64d is potentially useful in the treatment of developmental seizure-induced brain damage both by regulating abnormal zinc signal transduction and through the modulation of altered lipid metabolism via ApoE/clusterin pathway in hippocampus.
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