AS252424

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01892CAS No. ：900515-16-4Purity：98%

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CAS No.	900515-16-4	Cat. No.	BCP01892
Name	AS252424
Synonyms	AS 252424;AS-252424;
SMILES
Chemical Name
Formula	C14H8FNO4S	M. Wt	305.28
Purity	98%	Storage	Store at 4-8°C
Description	AS-252424 shows reduced potency on PI3Kα with an IC50 with 935 nM. When screening against 80 different Ser/Thr and Tyr kinases, AS-252424 doesn't show significant inhibit towards any of them at 10 μM except for CK2. AS-252424 inhibits C5a-mediated PKB/Akt phosphorylation in a concentration- dependent manner with submicromolar or low-micromolar IC50 value. AS-252424 inhibits MCP-1-mediated chemotaxis in wild-type primary monocytes in a concentration-dependent manner with an IC50 value of 52 μM, as well as in the monocytic cell line THP-1 with an IC50 value of 53 μM. AS252424 specifically blocks proliferation in the pancreatic cancer cell lines HPAF and Capan1, as assessed by cell counting. A recent research indicates 100 nM of AS-252424 significantly reduces [Ca2+]i, ICa and Ca2+ transients in HL-1 cardiomyocytes.