E7016 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP46932CAS No. ：902128-92-1Purity：98%

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CAS No.	902128-92-1	Cat. No.	BCP46932
Name	E7016
Synonyms	E-7016; E 7016; GPI21016; GPI 21016; GPI-21016;
SMILES	C1CN(CCC1O)CC2=CC3=C(C=C2)OC4=CC=CC5=C4C3=NNC5=O
Chemical Name
Formula	C20H19N3O3	M. Wt	349.38
Purity	98%	Storage	Store at 4-8°C
Description	E7016, also known as GPI21016, is an inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with potential chemo- and/or radiosensitizing activity. PARP inhibitor E7016 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks and promotes genomic instability and eventually leads to apoptosis. In addition, this agent may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks.