Navitoclax New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01724CAS No. ：923564-51-6Purity：99%

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CAS No.	923564-51-6	Cat. No.	BCP01724
Name	Navitoclax
Synonyms	ABT-263;ABT 263;ABT263;
SMILES	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Chemical Name
Formula	C47H55ClF3N5O6S3	M. Wt	974.61
Purity	99%	Storage	Store at 4-8°C
Description	Navitoclax is an orally active, synthetic small molecule and an antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. Navitoclax selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w, which are frequently overexpressed in a wide variety of cancers, including those of the lymph, breast, lung, prostate, and colon, and are linked to tumor drug resistance. Inhibition of these apoptosis suppressors prevents their binding to the apoptotic effectors Bax and Bak proteins, thereby triggering apoptotic processes in cells overexpressing Bcl-2, Bcl-XL, and Bcl-w. This eventually reduces tumor cell proliferation.