VTX-2337
Data Sheet
For research use only. Not for human use.
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| CAS No. | 926927-61-9 | Cat. No. | BCP16667 |
| Name | VTX-2337 | ||
| Synonyms | VTX 2337;VTX2337;Motolimod; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C28H34N4O2 | M. Wt | 458.6 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | VTX-2337 selectively activates TLR8 with an EC(50) of about 100 nmol/L and stimulates production of TNFα and interleukin (IL)-12 from monocytes and myeloid dendritic cells (mDC). VTX-2337 stimulates IFNγ production from NK cells and increases the cytotoxicity of NK cells against K562 and ADCC by rituximab and trastuzumab. Effects of VTX-2337 on NK cells were, in part, from direct activation as increased IFNγ production and cytotoxic activity were seen with purified NK cells. Finally, VTX-2337 augments ADCC by rituximab in PBMCs with different FcγR3A genotypes (V/V, V/F, and F/F at position 158). VTX-2337 is a novel small-molecule TLR8 agonist that activates monocytes, DCs, and NK cells. | ||
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