Pacritinib
Data Sheet
For research use only. Not for human use.
Get Quotation Now* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 937272-79-2 | Cat. No. | BCP09091 |
| Name | Pacritinib | ||
| Synonyms | SB1518;SB-1518;SB 1518; | ||
| SMILES | C1(C2=NC(NC3=CC=C(OCCN4CCCC4)C(COC/C=C/COC5)=C3)=NC=C2)=CC5=CC=C1 | ||
| Chemical Name | |||
| Formula | C28H32N4O3 | M. Wt | 472.25 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Pacritinib, also known as SB1518, is a n orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Pacritinib competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis. JAK2 is the most common mutated gene in bcr-abl-negative myeloproliferative disorders; the JAK2V617F gain-of-function mutation involves a valine-to-phenylalanine modification at position 617. The JAK-STAT signaling pathway is a major mediator of cytokine activity. | ||
Recommend Products
More >
-
QL-1200186
Cat. No.：BCP49631
No.：2848664-42-4
Product Details -
Filgotinib maleate
Cat. No.：BCP49095
No.：1802998-75-9
Product Details -
Pacritinib citrate
Cat. No.：BCP48998
No.：1228923-42-9
Product Details -
JAK-IN-5 hydrochloride
Cat. No.：BCP48031
No.：2751323-21-2
Product Details -
-
-
-
-
-
Ifidancitinib
Cat. No.：BCP46085
No.：1236667-40-5
Product Details -
Ritlecitinib tosylate
Cat. No.：BCP45991
No.：2192215-81-7
Product Details -
Deuruxolitinib phosphate
Cat. No.：BCP45990
No.：2147706-60-1
Product Details -
-
Tyk2-IN-5
Cat. No.：BCP45577
No.：1797432-62-2
Product Details -
Ilginatinib
Cat. No.：BCP44119
No.：1239358-86-1
Product Details -
Aurora B inhibitor 1
Cat. No.：BCP42843
No.：937276-52-3
Product Details -
-
Upadacitinib hemihydrate
Cat. No.：BCP41039
No.：2050057-56-0
Product Details -
Ruxolitinib racemic
Cat. No.：BCP25428
No.：1160597-27-2
Product Details -
Solcitinib
Cat. No.：BCP23893
No.：1206163-45-2
Product Details
Tags:Pacritinib supplier,Pacritinib purchase,Pacritinib manufacturer,Pacritinib distributor,Pacritinib cost,Pacritinib buy,Pacritinib for sale