VER-49009
Data Sheet
For research use only. Not for human use.
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| CAS No. | 940289-57-6 | Cat. No. | BCP09635 |
| Name | VER-49009 | ||
| Synonyms | VER49009; VER 49009; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H18ClN3O4 | M. Wt | 387.82 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM. It produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel. Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis. | ||
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