Mericitabine New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 940908-79-2 | Cat. No. | BCP13789 |
| Name | Mericitabine | ||
| Synonyms | RG7128; RG-7128; RG 7128; R-7128; R7128; R 7128; PSI 6130 diisobutyrate; | ||
| SMILES | CC(C)C(=O)OCC1C(C(C(O1)N2C=CC(=NC2=O)N)(C)F)OC(=O)C(C)C | ||
| Chemical Name | |||
| Formula | C18H26FN3O6 | M. Wt | 399.41 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Mericitabine is an orally available prodrug of PSI-6130 which is a selective cytidine nucleoside analogue and non-cytotoxic hepatitis C virus (HCV) polymerase inhibitor. After intracellular uptake, mericitabine is phosphorylated into two active triphosphate metabolites, which disable HCV RNA-dependent RNA polymerase (non-structural protein 5B; NS5B) upon binding. This results in the blockage of viral HCV RNA production and thus viral replication. This agent has a high barrier to resistance, however, a substitution mutation (S282T) on HCV NS5B impairs mericitabine's activity significantly. | ||
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