AZ304 New
Data Sheet
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| CAS No. | 942507-42-8 | Cat. No. | BCP31900 |
| Name | AZ304 | ||
| Synonyms | AZ-304; AZ 304; | ||
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=NC=NC4=C3C=CC(=C4)OC | ||
| Chemical Name | |||
| Formula | C27H25N5O2 | M. Wt | 451.53 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79 nM and 38 nM, respectively. | ||
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