Exarafenib New
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| CAS No. | 2639957-39-2 | Cat. No. | BCP49200 |
| Name | Exarafenib | ||
| Synonyms | RAF/KIN_2787; KIN-2787; KIN 2787; KIN2787; | ||
| SMILES | CC1=C(C=C(C=C1)NC(=O)N2CCC(C2)CC(F)(F)F)C3=CC(=NC(=C3)N4CCOCC4)NC(C)CO | ||
| Chemical Name | |||
| Formula | C26H34F3N5O3 | M. Wt | 521.58 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Exarafenib is an orally available inhibitor of class I, II, and III B-Raf (BRAF) protein kinases, with potential antineoplastic activity. Upon administration, exarafenib binds to and inhibits Class I, Class II, or Class III B-Raf mutations. This prevents B-Raf-mediated signal transduction pathways, which may lead to an inhibition of tumor growth in B-Raf mutant cells. B-Raf protein kinases play a key role in the RAF/MEK/ERK signaling pathway, which is often deregulated and mutated in human cancers, and plays a key role in tumor cell proliferation and survival. | ||
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