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Peficitinib Chemical Structure

Peficitinib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP18465CAS No. ：944118-01-8Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 944118-01-8 Cat. No. BCP18465
Name Peficitinib
Synonyms ASP015K;JNJ-54781532;ASP-015K;ASP 015K;JNJ54781532;JNJ 54781532;
SMILES
Chemical Name
Formula C18H22N4O2 M. Wt 310.39
Purity 98% Storage Store at 4-8°C
Description Peficitinib (ASP015K) is a novel orally bioavailable JAK inhibitor in development for the treatment of severe rheumatoid arthritis (RA). Milder inhibition of JAK2 by Peficitinib may contribute to the mitigation of effects on red blood cells and platelets reported to be caused by JAK2 inhibition. Moreover, Peficitinib has shown an improvement in symptoms in RA animal models after once-daily oral administration, and has demonstrated dose-dependent improvement in psoriatic disease activities in a 6-week phase IIa study. The terminal mean half-life of Peficitinib was estimated to be 7-13 h in pharmacological studies with healthy subjects, suggesting that Peficitinib can be dosed once-daily in the next development stage.
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