Decernotinib
Data Sheet
For research use only. Not for human use.
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| CAS No. | 944842-54-0 | Cat. No. | BCP09807 |
| Name | Decernotinib | ||
| Synonyms | VX-509;VX509;VX 509;VRT-831509;VRT 831509;VRT831509; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C18H19F3N6O | M. Wt | 392.38 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | VX-509 potently inhibits JAK3 in enzyme assays (Ki =2.5 nM + 0.7 nM) and cellular assays dependent on JAK3 activity (IC50 range, 50-170 nM), with limited or no measurable potency against other JAK isotypes or non-JAK kinases. in vivo: VX-509 also showed activity in two animal models of aberrant immune function. VX-509 treatment resulted in dose-dependent reduction in ankle swelling and paw weight and improved paw histopathology scores in the rat collagen-induced arthritis (CIA) model. In a mouse model of oxazolone-induced delayed-type hypersensitivity (DTH), VX-509 reduced the T-cell-mediated inflammatory response in skin. | ||
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