Beclabuvir hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 958002-36-3 | Cat. No. | BCP11012 |
| Name | Beclabuvir hydrochloride | ||
| Synonyms | Beclabuvir HCl；BMS-791325 hydrochloride; BMS791325 HCl; BMS 791325 hydrochloride; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C36H45N5O5S.HCl | M. Wt | 696.3 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Beclabuvir, also known as BMS-791325, is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC50) below 28 nM. In cell culture, BMS-791325 inhibited replication of HCV subgenomic replicons representing genotypes 1a and 1b at 50% effective concentrations (EC50s) of 3 nM and 6 nM, respectively, with similar (3 to 18 nM) values for genotypes 3a, 4a, and 5a. BMS-791325 was found to have distinguishing antiviral, safety, and pharmacokinetic properties that resulted in its selection for clinical evaluation. | ||
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