SNX-5422
Data Sheet
For research use only. Not for human use.
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| CAS No. | 908115-27-5 | Cat. No. | BCP02427 |
| Name | SNX-5422 | ||
| Synonyms | SNX5422;PF-04929113;PF 04929113;PF04929113;SNX 5422; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C25H30F3N5O4 | M. Wt | 521.53 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF-04929113 is a small-molecule Hsp90 inhibitor based on the 6,7-dihydro-indazol-4-one scaffold. PF-04929113 developed by Serenex, converts to SNX-2122, which is the active Hsp90 inhibitor form. PF-04929113 exhibits potent effects on Her-2 stability and causes expected up-regulation of Hsp70. PF-04929113 shows potent antiproliferative activity against a broad range of cancer cell types, e.g. MCF-7 (IC50=16 nM), SW620 (IC50=19 nM), K562 (IC50=23 nM), SK-MEL-5 (IC50=25 nM), and A375 (IC50=51 nM). | ||
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