Fostamatinib disodium New
Data Sheet
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| CAS No. | 1025687-58-4 | Cat. No. | BCP02850 |
| Related Products | 901119-35-5（Fostamatinib） 914295-16-2（Fostamatinib disodium hexahydrate） | ||
| Name | Fostamatinib disodium | ||
| Synonyms | prodrug of R-406;R935788 sodium;R-788;R 788;R788 disodium;R935788; R-935788; R 935788; | ||
| SMILES | CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+] | ||
| Chemical Name | |||
| Formula | C23H24FN6O9P.2Na | M. Wt | 624.42 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Fostamatinib Disodium Anhydrous is the anhydrous form of fostamatinib disodium, an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities. R935788 is a methylene phosphate prodrug of R406, which can be rapidly converted to R406 in vivo. R406 (in vitro active form of R935788) selectively inhibits Syk-dependent signaling with EC50 values ranging from 33 nM to 171 nM, more potently than Syk-independent pathways in different cells.R406 inhibits cellular proliferation of a variety of diffuse large B-cell lymphoma (DLBCL) cell lines with EC50 values ranging from 0.8 μM to 8.1 μM.R406 treatment reduces basal phosphorylation of BLNK, Akt, glycogen synthase kinase-3 (GSK-3), forkhead box O (FOXO) and ERK not only in cells with high (TCL-002) but also in cells with low levels of phosphorylated Syk (TCL1-551). | ||
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